Induction of the estrogen specific mitogenic response of MCF-7 cells by selected analogues of estradiol-17 beta: a 3D QSAR study.

@article{Wiese1997InductionOT,
  title={Induction of the estrogen specific mitogenic response of MCF-7 cells by selected analogues of estradiol-17 beta: a 3D QSAR study.},
  author={Thomas E. Wiese and Lisa Anne Polin and E. Orusco Palomino and S. Courtnie Brooks},
  journal={Journal of medicinal chemistry},
  year={1997},
  volume={40 22},
  pages={
          3659-69
        }
}
Analogues of estradiol-17 beta (E2) have been evaluated for estrogen receptor (ER) binding affinity and mitogenic potential in the human breast cancer cell line MCF-7. These 42 compounds represent subtle modifications of the natural estrogen structure through the placement of hydroxyl, amino, nitro, or iodo groups around the ring system in addition to, or as replacement of, the 3- and 17 beta-hydroxyls of E2. The mitogenic activity of the analogues was found to be related to ER binding only to… CONTINUE READING
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