Induction of the antigen receptor expression on B lymphocytes results in rapid competence for signaling of SLP-65 and Syk.

@article{Zhang1998InductionOT,
  title={Induction of the antigen receptor expression on B lymphocytes results in rapid competence for signaling of SLP-65 and Syk.},
  author={Yuexing Zhang and J{\"u}rgen Wienands and Christa Z{\"u}rn and Michael Reth},
  journal={The EMBO journal},
  year={1998},
  volume={17 24},
  pages={7304-10}
}
The binding of antigen to the B cell antigen receptor (BCR) results in the activation of protein tyrosine kinases (PTKs) such as Lyn and Syk, and the phosphorylation of several substrate proteins including HS1 and SLP-65. How these signaling elements are connected to the BCR is not well understood. Using an expression vector for a tamoxifen-regulated Cre recombinase, we have developed a method that allows the inducible expression of the BCR. Disruption of the VH leader reading frame of the… CONTINUE READING
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