Induction of the Wnt Antagonist Dickkopf-1 Is Involved in Stress-Induced Hippocampal Damage

@inproceedings{Matrisciano2011InductionOT,
  title={Induction of the Wnt Antagonist Dickkopf-1 Is Involved in Stress-Induced Hippocampal Damage},
  author={F. Matrisciano and Carla L Busceti and Domenico Bucci and Rosamaria Orlando and Alessandra Caruso and Gemma Molinaro and Irene Cappuccio and Barbara Riozzi and R. Sale P. Gradini and Marta Motolese and Filippo Caraci and Agata G. Copani and Sergio Scaccianoce and Daniela Melchiorri and Valeria Bruno and Giuseppe Battaglia and Ferdinando Nicoletti},
  booktitle={PloS one},
  year={2011}
}
The identification of mechanisms that mediate stress-induced hippocampal damage may shed new light into the pathophysiology of depressive disorders and provide new targets for therapeutic intervention. We focused on the secreted glycoprotein Dickkopf-1 (Dkk-1), an inhibitor of the canonical Wnt pathway, involved in neurodegeneration. Mice exposed to mild restraint stress showed increased hippocampal levels of Dkk-1 and reduced expression of β-catenin, an intracellular protein positively… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 20 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 71 REFERENCES

Similar Papers

Loading similar papers…