Induction of the MMP-14 gene in macrophages of the atherosclerotic plaque: role of SAF-1 in the induction process.

@article{Ray2004InductionOT,
  title={Induction of the MMP-14 gene in macrophages of the atherosclerotic plaque: role of SAF-1 in the induction process.},
  author={B. K. Ray and Arvind Shakya and James R. Turk and Suneel S. Apte and Alpana Ray},
  journal={Circulation research},
  year={2004},
  volume={95 11},
  pages={
          1082-90
        }
}
Based on epidemiological and pathological studies, it is becoming increasingly clear that matrix metalloproteinases (MMPs) play an important role in the pathogenesis of atherosclerosis by participating in vascular remodeling, smooth muscle cell migration, and plaque disruption. MMP-14, because of its unique ability to cause pericellular degradation, its broad substrate specificity, its synthesis in an active form, and its ability to activate other matrix metalloproteinases, is recognized as a… CONTINUE READING

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