Induction of the Escherichia coli lactose operon selectively increases repair of its transcribed DNA strand

@article{Mellon1989InductionOT,
  title={Induction of the Escherichia coli lactose operon selectively increases repair of its transcribed DNA strand},
  author={Isabel Mellon and Philip C. Hanawalt},
  journal={Nature},
  year={1989},
  volume={342},
  pages={95-98}
}
NUCLEOTIDE excision repair helps to ameliorate the lethal and mutagenic consequences of DNA damage by removing helix-distorting lesions from cellular genomes1. We have pre-viously analysed the removal of ultraviolet-induced cyclobutane pyrimidine dimers from specific DNA sequences in mammalian cells and demonstrated that transcriptionally active genes are preferentially repaired2–4. Additionally, we found that in rodent and human cells only the transcribed strand of the dihydrofolate reductase… CONTINUE READING

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