Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner.

  title={Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner.},
  author={Dimitri Lodygin and Antje Menssen and Heiko Hermeking},
  journal={The Journal of clinical investigation},
  volume={110 11},
Using microarray analysis, we have detected downregulation of several components of the cGMP signaling pathway during replicative senescence of primary human diploid fibroblasts (HDFs). Therefore, the effect of pharmacological inhibition of cGMP synthesis was analyzed in HDFs. Treatment with 6-anilino-5,8-quinolinequinone (LY83583, referred to as LY hereafter), a previously described inhibitor of guanylate cyclase, induced cellular senescence. Microarray analysis revealed that LY treatment… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 25 extracted citations

Transcriptional networks and cellular senescence in human mammary fibroblasts.

Molecular biology of the cell • 2005
View 4 Excerpts
Highly Influenced

Role of p53 in the progression from ochratoxin A-induced DNA damage to gene mutations in the kidneys of mice.

Toxicological sciences : an official journal of the Society of Toxicology • 2015
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 48 references

A new mathematical model for relative quantification in real-time RT-PCR.

Nucleic acids research • 2001
View 3 Excerpts
Highly Influenced

Characterization of the c-MYC-regulated transcriptome by SAGE: identification and analysis of c-MYC target genes.

Proceedings of the National Academy of Sciences of the United States of America • 2002
View 1 Excerpt

Therapy-associated solid tumors.

Acta oncologica • 2002
View 1 Excerpt

Cellular senescence as a tumor-suppressor mechanism.

Trends in cell biology • 2001
View 1 Excerpt

Putting the stress on senescence.

Current opinion in cell biology • 2001
View 1 Excerpt

Similar Papers

Loading similar papers…