Induction of the Angiogenic Phenotype by Hox D3

  title={Induction of the Angiogenic Phenotype by Hox D3 },
  author={Nancy Boudreau and C. Andrews and Anabella Srebrow and Ali Ravanpay and David A. Cheresh},
  journal={The Journal of Cell Biology},
  pages={257 - 264}
Angiogenesis is characterized by distinct phenotypic changes in vascular endothelial cells (EC). Evidence is provided that the Hox D3 homeobox gene mediates conversion of endothelium from the resting to the angiogenic/invasive state. Stimulation of EC with basic fibroblast growth factor (bFGF) resulted in increased expression of Hox D3, integrin alphavbeta3, and the urokinase plasminogen activator (uPA). Hox D3 antisense blocked the ability of bFGF to induce uPA and integrin alphavbeta3… CONTINUE READING