Induction of tenascin-C by cyclic tensile strain versus growth factors: distinct contributions by Rho/ROCK and MAPK signaling pathways.

@article{Chiquet2004InductionOT,
  title={Induction of tenascin-C by cyclic tensile strain versus growth factors: distinct contributions by Rho/ROCK and MAPK signaling pathways.},
  author={Matthias Chiquet and Ana Sarasa-Renedo and Vildan Tunç-Civelek},
  journal={Biochimica et biophysica acta},
  year={2004},
  volume={1693 3},
  pages={
          193-204
        }
}
Expression of the extracellular matrix (ECM) protein tenascin-C is induced in fibroblasts by growth factors as well as by tensile strain. Mechanical stress can act on gene regulation directly, or indirectly via the paracrine release of soluble factors by the stimulated cells. To distinguish between these possibilities for tenascin-C, we asked whether cyclic tensile strain and soluble factors, respectively, induced its mRNA via related or separate mechanisms. When cyclic strain was applied to… CONTINUE READING
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