Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice.

@article{Bolmont2007InductionOT,
  title={Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice.},
  author={Tristan Bolmont and Florence Clavaguera and Melanie Meyer-Luehmann and Martin Christian Herzig and Rebecca Radde and Matthias Staufenbiel and Jada Lewis and Mike Hutton and Markus Tolnay and Mathias Jucker},
  journal={The American journal of pathology},
  year={2007},
  volume={171 6},
  pages={2012-20}
}
Alzheimer's disease presents morphologically with senile plaques, primarily made of extracellular amyloid-beta (A beta) deposits, and neurofibrillary lesions, which consist of intracellular aggregates of hyperphosphorylated tau protein. To study the in vivo induction of tau pathology, dilute brain extracts from aged A beta-depositing APP23 transgenic mice were intracerebrally infused in young B6/P301L tau transgenic mice. Six months after the infusion, tau pathology was induced in the injected… CONTINUE READING

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