Induction of syngeneic graft-versus-host disease in LPS hyporesponsive C3H/HeJ mice.

@article{Flanagan2001InductionOS,
  title={Induction of syngeneic graft-versus-host disease in LPS hyporesponsive C3H/HeJ mice.},
  author={Donna L. Flanagan and Ren{\'e} Gross and Chester D. Jennings and Betty E. Caywood and Sarah W. Goes and Alan M. Kaplan and James S. Bryson},
  journal={Journal of leukocyte biology},
  year={2001},
  volume={70 6},
  pages={873-80}
}
Syngeneic GVHD (SGVHD) develops following syngeneic bone marrow transplantation and treatment with cyclosporine A. Previous studies have demonstrated a role for IL-12, IFN-gamma, and TNF-alpha in the development of murine SGVHD. Macrophages can be activated to secrete IL-12 and TNF-alpha via a T-cell-dependent or T-cell-independent pathway (LPS or bacterial products). Studies were designed to determine if LPS participated in the development of SGVHD in C3H/HeN (LPS-responsive) and C3H/HeJ (LPS… CONTINUE READING

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