Induction of synaptic development in cultured muscle cells by basic fibroblast growth factor

@article{Peng1991InductionOS,
  title={Induction of synaptic development in cultured muscle cells by basic fibroblast growth factor},
  author={H. Benjamin Peng and Lauren P. Baker and Qiming Chen},
  journal={Neuron},
  year={1991},
  volume={6},
  pages={237-246}
}
The role of basic fibroblast growth factor (bFGF) in signaling the development of the neuromuscular junction was examined. Beads coated with bFGF induced the formation of acetylcholine receptor (AChR) clusters in cultured Xenopus myotomal muscle cells. Tyrphostin, a tyrosine kinase inhibitor, abolished AChR clustering induced by bFGF beads, suggesting a role of tyrosine kinase activation in AChR clustering. Using specific antibodies, we demonstrated the presence of both bFGF and its receptor in… CONTINUE READING

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