Induction of susceptibility to tumor necrosis factor by E1A is dependent on binding to either p300 or p105-Rb and induction of DNA synthesis.

@article{Shisler1996InductionOS,
  title={Induction of susceptibility to tumor necrosis factor by E1A is dependent on binding to either p300 or p105-Rb and induction of DNA synthesis.},
  author={Joanna L Shisler and Penelope Jayne Duerksen-Hughes and Terry Hermiston and William S. M. Wold and Linda R. Gooding},
  journal={Journal of virology},
  year={1996},
  volume={70 1},
  pages={68-77}
}
The introduction of the adenovirus early region 1A (E1A) gene products into normal cells sensitizes these cells to the cytotoxic effects of tumor necrosis factor (TNF). Previous studies have shown that the region of E1A responsible for susceptibility is CR1, a conserved region within E1A which binds the cellular proteins p300 and p105-Rb at nonoverlapping sites. Binding of these and other cellular proteins by E1A results in the induction of E1A-associated activities such as transformation… CONTINUE READING