Induction of suppressors of cytokine signaling by the trichothecene deoxynivalenol in the mouse.

@article{Amuzie2009InductionOS,
  title={Induction of suppressors of cytokine signaling by the trichothecene deoxynivalenol in the mouse.},
  author={Chidozie J Amuzie and Junko Shinozuka and James J. Pestka},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2009},
  volume={111 2},
  pages={277-87}
}
Deoxynivalenol (DON), a trichothecene mycotoxin found in grains and cereal-based foods worldwide, impairs weight gain in experimental animals but the underlying mechanisms remain undetermined. Oral exposure to DON induces rapid and transient upregulation of proinflammatory cytokine expression in the mouse. The latter are known to induce several suppressors of cytokine signaling (SOCS), some of which impair growth hormone (GH) signaling. We hypothesized that oral exposure to DON will induce SOCS… CONTINUE READING