Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.

@article{Yokota2004InductionOS,
  title={Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.},
  author={Shin-Ichi Yokota and Noriko Yokosawa and Tamaki Okabayashi and Tatsuo Suzutani and Shunsuke Miura and Kowichi Jimbow and Nobuhiro Fujii},
  journal={Journal of virology},
  year={2004},
  volume={78 12},
  pages={6282-6}
}
We showed previously that herpes simplex virus type 1 (HSV-1) suppresses the interferon (IFN) signaling pathway during the early infection stage in the human amnion cell line FL. HSV-1 inhibits the IFN-induced phosphorylation of Janus kinases (JAK) in infected FL cells. In the present study, we showed that the suppressor of cytokine signaling-3 (SOCS3), a host negative regulator of the JAK/STAT pathway, is rapidly induced in FL cells after HSV-1 infection. Maximal levels of SOCS3 protein were… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 58 extracted citations

Viral exploitation of host SOCS protein functions.

Journal of virology • 2011
View 11 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 48 references

IFN-alpha antagonistic activity of HCV core protein involves induction of suppressor of cytokine signaling-3.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2003

stitutive Stat 3 , Tyr 705 , and Ser 727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin - 6

H. Inoue, N. Nagata, +13 authors M. Kubo
Blood • 2003

Similar Papers

Loading similar papers…