[Induction of stromal cell transformation in xenografts of human colonic cancer].

Abstract

Two transformed stromal cell lines FM-7 and FR-7 were obtained from human xenografts of colon tumor (HCT-7), propagated in nude mice and nude rats, respectively. These two cell lines were confirmed to be murine and rat's by a cytogenetic study and were tumourigenic in BALB/c nude mice with the morphology of fibrosarcoma. Human DNA sequences were not detected by hybridization with pBlur8 probe in DNA of FR-7 cell line grown in vitro. These results indicate that human cancer cells from xenograft HCT-7 can induce malignancy in adjacent normal cells of nude mice and nude rats in the absence of DNA transfer.

Cite this paper

@article{Bryzgalov1992InductionOS, title={[Induction of stromal cell transformation in xenografts of human colonic cancer].}, author={I. P. Bryzgalov and T V Iudicheva and S. A. Galetskii and Iu N Solov'ev and Elena Revazova}, journal={Biulleten' eksperimental'noĭ biologii i meditsiny}, year={1992}, volume={113 4}, pages={399-402} }