Induction of striatal neurogenesis enhances functional recovery in an adult animal model of neonatal hypoxic-ischemic brain injury.

@article{Im2010InductionOS,
  title={Induction of striatal neurogenesis enhances functional recovery in an adult animal model of neonatal hypoxic-ischemic brain injury.},
  author={S H Im and Ji Hea Yu and Eun Sook Park and Jung Eun Lee and Hee Ok Kim and Kook In Park and Gyung Whan Kim and Chang Il Park and S Cho},
  journal={Neuroscience},
  year={2010},
  volume={169 1},
  pages={259-68}
}
While intraventricular administration of epidermal growth factor (EGF) expands the proliferation of neural stem/progenitor cells in the subventricular zone (SVZ), overexpression of brain-derived neurotrophic factor (BDNF) is particularly effective in enhancing striatal neurogenesis. We assessed the induction of striatal neurogenesis and consequent functional recovery after chronic infusion of BDNF and EGF in an adult animal model of neonatal hypoxic-ischemic (HI) brain injury. Permanent brain… CONTINUE READING

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