Induction of specific storage organelles by von Willebrand factor propolypeptide.

  title={Induction of specific storage organelles by von Willebrand factor propolypeptide.},
  author={Denisa D Wagner and Simin Saffaripour and R Bonfanti and J Evan Sadler and Elisabeth M. Cramer and Brandon Chapman and Tanya Norton Mayadas},
  volume={64 2},
Endothelial cells store the multimeric adhesive glycoprotein von Willebrand factor (vWf), which promotes the formation of a platelet plug at the site of vessel injury. To investigate the packaging of vWf into the granules called Weibel-Palade bodies, we expressed pro-vWf cDNA and cDNA lacking the prosequence in a variety of cell lines. Storage granules formed only in cells that contain a regulated pathway of secretion. Furthermore, packaging required the prosequence. Pro-vWf, lacking the C… CONTINUE READING

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