Induction of skin papillomas, carcinomas, and sarcomas in mice in which the connexin 43 gene is heterologously deleted.

@article{Yamakage2000InductionOS,
  title={Induction of skin papillomas, carcinomas, and sarcomas in mice in which the connexin 43 gene is heterologously deleted.},
  author={Kei Yamakage and Yasufumi Omori and Maria L{\'u}cia ZAIDAN-DAGLI and Marie Pierre Cros and Hiroshi Yamasaki},
  journal={The Journal of investigative dermatology},
  year={2000},
  volume={114 2},
  pages={
          289-94
        }
}
It has been suggested that blocked gap junctional intercellular communication plays a crucial part in multistage carcinogenesis. The mouse skin tumor-promoting phorbol esters are potent inhibitors of gap junctional intercellular communication and this inhibition is considered to be a mechanism by which clonal expansion of "initiated" cells is promoted. We examined whether mice in which the gene for a gap junction protein, connexin 43, is heterozygously deleted are more susceptible to chemical… CONTINUE READING

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