Induction of skin carcinogenicity by alcohol and ultraviolet light

@article{Saladi2010InductionOS,
  title={Induction of skin carcinogenicity by alcohol and ultraviolet light},
  author={Rao N. Saladi and Tatyana Nektalova and Joshua L. Fox},
  journal={Clinical and Experimental Dermatology},
  year={2010},
  volume={35}
}
In western societies, casual consumption of alcohol during such outdoor activities as barbecuing and sunbathing is common. The current literature shows that alcohol drinkers have increased episodes of sunburn and a higher prevalence of skin cancer. Moreover, recent evidence suggests that the combination of subcarcinogenic (minimal) ultraviolet (UV) exposure with other behavioural, environmental and xenobiotic factors has resulted in increased incidents of skin‐related health problems that also… 

Ultraviolet Radiation and Basal Cell Carcinoma: An Environmental Perspective

This chapter follows the function of UVR in the onset and development of BCC, and describes the factors that influence BCC induced by UVR, and also reviews the recent advances of pathogenesis of BCC inducedBy UVR from the genetic and inflammatory aspects.

Alcohol Consumption Decreases the Protection Efficiency of the Antioxidant Network and Increases the Risk of Sunburn in Human Skin

A significant decrease in the carotenoid concentration in the skin and the minimal erythema dose after alcohol consumption was shown, but no significant decrease after a combined intake of alcohol and orange juice.

An Epidemiological Review of Diet and Cutaneous Malignant Melanoma

A narrative review to summarize recent epidemiologic studies of diet and melanoma based on published literature finds associations between polyunsaturated fatty acid, niacin/nicotinamide, folate, and vitamin D with melanoma remain controversial.

Alcohol And Early-Onset Basal Cell Carcinoma In A Case-Control Study

Although there was no statistically significant association between lifetime alcohol intake and early-onset BCC overall, there was a positive association in those with relatively high UV exposures from indoor tanning/sunbathing.

Alcohol as a Non-UV Social-Environmental Risk Factor for Melanoma

A perspective review paper summarizes epidemiological data correlating melanoma incidence with alcohol consumption, describes the biochemical mechanisms of ethanol metabolism, and discusses how ethanol and ethanol metabolites contribute to human cancer, including melanoma.

Alcohol consumption and risk of cutaneous basal cell carcinoma in women and men: 3 prospective cohort studies.

Increased alcohol intake was associated with increased BCC risk in both women and men and the association remained consistent when the authors used alcohol intakes over different latency periods as exposures and over categories of sun exposure-related factors.

Light alcohol drinking and the risk of cancer development: a controversial relationship.

Light alcohol drinking was not associated with an increased risk of cancer occurrence, with the exception of breast and prostate cancer and melanoma, and a possible protective role of light alcohol consumption on the development of bladder, kidney and ovarian cancer and Non Hodgkin Lymphoma was shown.

Alcohol Intake and Risk of Incident Melanoma

None of the other beverage categories that the authors analyzed (red wine, beer, liquor) showed any association with either invasive melanoma or melanoma in situ in any cohort or pooled analysis.

Intake of alcohol may modify the risk for non-melanoma skin cancer: results of a large Danish prospective cohort study.

It is indicated that alcohol intake may increase the risk for BCC, but the relations seemed to depend on beverage type, possibly because of the limited number of cases.

Light alcohol drinking and the risk of developing cancer, a systematic review.

It is found that light alcohol drinking do not determine a higher risk for the insurgence of several malignancies, except for a light increase in the incidence of melanoma, breast cancer in women and prostate cancer in men.
...

References

SHOWING 1-10 OF 37 REFERENCES

The epidemiology of UV induced skin cancer.

Arsenite is a cocarcinogen with solar ultraviolet radiation for mouse skin: an animal model for arsenic carcinogenesis.

The results suggest that the failure to find an animal model for arsenic carcinogenesis is because arsenite is not a carcinogen per se, but rather acts as an enhancing agent (cocarcinogen) with a genotoxic partner.

Skin Effects of Air Pollution

  • Lowell A. Goldsmith
  • Environmental Science, Medicine
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • 1996

Alcohol Consumption and the Risk of Cancer: A Meta-Analysis

A combined analysis of more than 200 studies assessing the link between alcohol and various types of cancer sought to investigate this association in more detail found that alcohol most strongly increased the risks for cancers of the oral cavity, pharynx, esophagus, and larynx.

Photocarcinogenesis: UVA vs. UVB Radiation

Experiments have shown that UVA1 (340–400 nm) exposure induces SCC largely without the characteristic point mutations in p53, and much of the mutagenic and carcinogenic action of UVA radiation appears to be mediated through reactive oxygen species (ROS).

Photocarcinogenesis: UVA vs. UVB Radiation

Experiments have shown that UVA1 (340–400 nm) exposure induces SCC largely without the characteristic point mutations in p53, and much of the mutagenic and carcinogenic action of UVA radiation appears to be mediated through reactive oxygen species (ROS).

Intake of alcohol and alcoholic beverages and the risk of basal cell carcinoma of the skin.

Alcohol intake was associated with BCC, but the association appeared to be different for each type of alcoholic beverage, and red wine appeared to have an inverse association in women but not in men.

The Combination of Benzo[a]pyrene and Ultraviolet A Causes an In Vivo Time-related Accumulation of DNA Damage in Mouse Skin¶

Investigation of in vivo cellular changes related to carcinogenesis induced by repeated exposures to BaP plus UVA found that cells containing BPDE–DNA adducts and nuclear p53 expression significantly increased between 2 and 10 weeks of BaP–UVA treatment, whereas neither BPDEs nor significant changes in p53 were observed in untreated skin.