Induction of sister chromatid exchange by 3,4-expoxybutane-1,2-diol in cultured human lymphocytes of different GSTT1 and GSTM1 genotypes.

@article{Bernardini1996InductionOS,
  title={Induction of sister chromatid exchange by 3,4-expoxybutane-1,2-diol in cultured human lymphocytes of different GSTT1 and GSTM1 genotypes.},
  author={Sabrina Bernardini and Katarina Pelin and K Peltonen and Hilkka J{\"a}rventaus and Ari P Hirvonen and Christina Neagu and Marja Sorsa and Hannu Norppa},
  journal={Mutation research},
  year={1996},
  volume={361 2-3},
  pages={121-7}
}
The induction of sister chromatid exchanges (SCEs) by a 48-h treatment with 3,4-epoxybutane-1,2-diol (EBD), a metabolite of 1,3-butadiene, was studied in whole-blood lymphocyte cultures of 22 human donors with known genotypes of two polymorphic glutathione S-transferases (GSTs), GSTT1 and GSTM1. For both genes, donors representing a homozygous 'null' genotype lacking the respective GST gene and isozyme and a 'positive' genotype with at least one intact gene and GST activity were included. The… CONTINUE READING