Induction of sister chromatic exchanges and inhibition of cellular proliferation in vitro. I. Caffeine.

@article{Guglielmi1982InductionOS,
  title={Induction of sister chromatic exchanges and inhibition of cellular proliferation in vitro. I. Caffeine.},
  author={Gwen E. Guglielmi and Thomas F. Vogt and Raymond Richard Tice},
  journal={Environmental mutagenesis},
  year={1982},
  volume={4 2},
  pages={191-200}
}
Cytogenetic assay systems based on the detection of sister chromatid exchanges (SCE) are widely advocated as a sensitive screening method for assessing genotoxic potential. While many agents have been examined for their ability to induce SCE's, complete dose-response information has often been lacking. We have reexamined the ability of one such compound-caffeine-to induce SCEs and also to inhibit cellular proliferation in human peripheral lymphocytes in vitro. An acute exposure to caffeine… CONTINUE READING

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