Induction of serine racemase expression and D-serine release from microglia by amyloid β-peptide

Abstract

Roles for excitotoxicity and inflammation in Alzheimer's disease have been hypothesized. Proinflammatory stimuli, including amyloid β-peptide (Aβ), elicit a release of glutamate from microglia. We tested the possibility that a coagonist at the NMDA class of glutamate receptors, D-serine, could respond similarly. Cultured microglial cells were exposed to A… (More)
DOI: 10.1186/1742-2094-1-2

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Cite this paper

@article{Wu2004InductionOS, title={Induction of serine racemase expression and D-serine release from microglia by amyloid β-peptide}, author={Sheng-Zhou Wu and Angela M Bodles and Mandy M Porter and W. Sue T. Griffin and Anthony S. Basile and Steven W. Barger}, journal={Journal of Neuroinflammation}, year={2004}, volume={1}, pages={2 - 2} }