Induction of sensitization to hyperactivity caused by morphine in mice: effects of post-drug environments.

@article{Kuribara1997InductionOS,
  title={Induction of sensitization to hyperactivity caused by morphine in mice: effects of post-drug environments.},
  author={Hisashi Kuribara},
  journal={Pharmacology, biochemistry, and behavior},
  year={1997},
  volume={57 1-2},
  pages={341-6}
}
Mice given five repeated administrations of morphine (10 mg/kg sc) at 3 day intervals in a round tilting-type activity cage (20 cm in diameter) or round spaces 15-30 cm in diameter with fixed floor showed almost the same level of ambulatory sensitization to morphine. Whereas, mice given morphine in the same schedule in spaces 4 and 12 cm, but not 6 and 9 cm, in diameter demonstrated a partial increase in the sensitivity to morphine. Furthermore, mice given morphine five times in a transparent… CONTINUE READING