Induction of selective inner hair cell damage by carboplatin.

@article{Takeno1994InductionOS,
  title={Induction of selective inner hair cell damage by carboplatin.},
  author={Shin-suke Takeno and Robert V. Harrison and Richard J. Mount and Melissa Wake and Yasuo Harada},
  journal={Scanning microscopy},
  year={1994},
  volume={8 1},
  pages={
          97-106
        }
}
Carboplatin (diammine [1,1 cyclobutane dicarboxylato (2)-0,0'] platinum) is an anti-cancer agent which can be toxic to the inner ear. We have explored the nature of this ototoxicity in the chinchilla. In this species, initial degenerative changes appear to be restricted to the inner hair cell (IHC) regions of the organ of Corti. This finding is intriguing and unusual since all other known ototoxic drugs, such as aminoglycosides, are predominantly associated with outer hair cell damage. In the… CONTINUE READING
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