Induction of reproducible brain infarction by photochemically initiated thrombosis

@article{Watson1985InductionOR,
  title={Induction of reproducible brain infarction by photochemically initiated thrombosis},
  author={Brant D. Watson and W. Dalton Dietrich and Raul Busto and Mitchell S Wachtel and Myron D. Ginsberg},
  journal={Annals of Neurology},
  year={1985},
  volume={17}
}
We have used a photochemical reaction in vivo to induce reprodcible thrombosis leading to cerebral infarction in rats. After the intravenous injection of rose bengal, a potent photosensitzing dye, an ischemic lesion was formed by irradiating the left parietal convexity of the exposed skull for 20 minutes with green light(560nm) from a filtered xenon arc lamp. Animals were allowed to surivive form 30 minutes to 15 days after irradiation. Early microscopic alerations within the irradiated zone… 
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