Induction of redox instability of bovine myoglobin by adduction with 4-hydroxy-2-nonenal.

@article{Alderton2003InductionOR,
  title={Induction of redox instability of bovine myoglobin by adduction with 4-hydroxy-2-nonenal.},
  author={Amy L Alderton and Cameron Faustman and Daniel C. Liebler and Dennis W. Hill},
  journal={Biochemistry},
  year={2003},
  volume={42 15},
  pages={4398-405}
}
The redox stability of myoglobin (Mb) is compromised by many factors, including lipid oxidation and its products. 4-Hydroxy-2-nonenal (HNE) is an alpha,beta-unsaturated aldehyde derived from the oxidation of omega-6 polyunsaturated fatty acids and is highly reactive and cytotoxic. Our objective was to study potential binding of HNE to Mb and determine how it affects redox stability. OxyMb (0.15 mM) was incubated with HNE (1 mM) at 4, 25, and 37 degrees C at pH 7.4 or 5.6. Samples were analyzed… CONTINUE READING

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