Induction of rat hepatic cytochrome P4501A and P4502B by the methoxsalen.

@article{Gwang1996InductionOR,
  title={Induction of rat hepatic cytochrome P4501A and P4502B by the methoxsalen.},
  author={J H Gwang},
  journal={Cancer letters},
  year={1996},
  volume={109 1-2},
  pages={115-20}
}
The effect of methoxsalen, the inhibitor of the hepatic mixed function oxidase, on the expression of liver cytochrome P450s was examined in rats. Administration of methoxsalen to rats significantly increased the hepatic content of P450 and activities of microsomal ethoxyresorufin O-deethylase (EROD), methoxyresorufin O-demethylase (MROD), pentoxyresorufin O-dealkylase (PROD), a representative activity of P4501A1, P4501A2 and P4502B1/2, respectively, in a dose-dependent manner. In contrast… CONTINUE READING

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