Induction of rat hepatic N-nitrosodimethylamine demethylase by acetone is due to protein stabilization.

@article{Song1989InductionOR,
  title={Induction of rat hepatic N-nitrosodimethylamine demethylase by acetone is due to protein stabilization.},
  author={B J Song and Richard L. Veech and Sung Sup Park and H. V. Gelboin and Frank J. Gonzalez},
  journal={The Journal of biological chemistry},
  year={1989},
  volume={264 6},
  pages={3568-72}
}
The N-nitrosodimethylamine demethylase (P450I-IE1) is induced severalfold in liver by giving rats ethanol, acetone, pyrazole, and other related small molecular weight compounds. This induction is not the result of an increase in IIE1 mRNA, but could be due to either an increase in translation rate or a decrease in protein degradation. To determine the mechanism of induction, we measured IIE1 synthesis and degradation rates in untreated and acetone-treated rats. This was accomplished by… CONTINUE READING

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References

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Showing 1-2 of 2 references

Mammalian Cytochromes P-450

  • P. B. Watkins, J. S. Bond, P. S. Guzelian
  • 1987

Biochem . J . 2 2 6 , Biophys . 263 , 29 - 35 Biochem . Biophys . Res . Commun . 150 , 436 - 443 ( 1987 )

  • R. T. Schimke
  • Biochem . Biophys . Res . Commun .
  • 1985

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