Induction of ram bone marrow mesenchymal stem cells into germ cell lineage using transforming growth factor-β superfamily growth factors.

@article{GhasemzadehHasankolaei2014InductionOR,
  title={Induction of ram bone marrow mesenchymal stem cells into germ cell lineage using transforming growth factor-β superfamily growth factors.},
  author={Mohammad Ghasemzadeh-Hasankolaei and Mohammad A Sedighi-Gilani and Mohamadreza Baghaban Eslaminejad},
  journal={Reproduction in domestic animals = Zuchthygiene},
  year={2014},
  volume={49 4},
  pages={588-598}
}
Several studies have proposed that in vitro generation of germ cells (GCs) from stem cells can be considered a future option for infertility treatment. Mesenchymal stem cells (MSCs) have the capability to differentiate into male GCs with the use of inducers such as retinoic acid. Transforming growth factor-beta 1 (TGFb1) has been shown to play important roles in male fertility and spermatogenesis. Bone morphogenic protein 4 (BMP4) and BMP8b are also involved in the derivation of primordial GCs… CONTINUE READING
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