Induction of quinone reductase NQO1 by resveratrol in human K562 cells involves the antioxidant response element ARE and is accompanied by nuclear translocation of transcription factor Nrf2.

@article{Hsieh2006InductionOQ,
  title={Induction of quinone reductase NQO1 by resveratrol in human K562 cells involves the antioxidant response element ARE and is accompanied by nuclear translocation of transcription factor Nrf2.},
  author={T. C. Hsieh and Xiaohua Lu and Zhirong Wang and Joseph M.W. Wu},
  journal={Medicinal chemistry (Shariqah (United Arab Emirates))},
  year={2006},
  volume={2 3},
  pages={275-85}
}
The phytochemical resveratrol has been reported to induce NQO1, an enzyme involved in detoxification reactions, by as yet undetermined mechanisms. Using K562 cells as a model, we showed that 25-50 microM resveratrol increased NQO1 that peaked at 24-48 h. A 2.5-fold rise in NQO1 protein levels was accompanied by a comparable elevation in mRNA copy number and a 3- to 5-fold increase in NQO1 enzymatic activity. Fluorescent microscopic analysis in combination with transfection experiments with… CONTINUE READING
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