Induction of quiescent S-phase cells by irradiation and/or hyperthermia. II. Correlation with colony forming ability.

@article{Zoelzer1993InductionOQ,
  title={Induction of quiescent S-phase cells by irradiation and/or hyperthermia. II. Correlation with colony forming ability.},
  author={Friedo Zoelzer and C. Streffer and Theo Pelzer},
  journal={International journal of radiation biology},
  year={1993},
  volume={63 1},
  pages={77-82}
}
Quiescent S-phase cells, i.e. cells with an S-phase DNA content that do not show BrdU incorporation, can be induced in a dose-dependent manner by irradiation and/or hyperthermia (Zölzer et al. 1992). As they begin to appear only 48-72 h after treatment, they do not seem to be related to early cell cycle disturbances, but rather to late events involved with cell death. We therefore determined colony forming ability under the same conditions, and tried to correlate the two parameters. Although… CONTINUE READING