Induction of quiescence (G0) in bone marrow stromal stem cells enhances their stem cell characteristics.

@article{Rumman2018InductionOQ,
  title={Induction of quiescence (G0) in bone marrow stromal stem cells enhances their stem cell characteristics.},
  author={Mohammad Abu Rumman and Abhijit Majumder and Linda Harkness and Balu Venugopal and Mathur Vinay and Malini S. Pillai and Moustapha Kassem and Jyotsna Dhawan},
  journal={Stem cell research},
  year={2018},
  volume={30},
  pages={
          69-80
        }
}
Several studies have suggested that bone marrow stromal steam cells (BMSC) exist in a quiescent state (G0) within the in vivo niche; however, an explicit analysis of the biology of G0 state-BMSC has not been reported. We hypothesized that induction of G0 in BMSC might enhance their stem cell properties. Thus, we induced quiescence in BMSC in vitro by (a) suspension culture in a viscous medium or (b) culture on soft polyacrylamide substrate; and examined their molecular and functional phenotype… CONTINUE READING
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