Induction of protective immunity by Legionella pneumophila flagellum in an A/J mouse model.

@article{Ricci2005InductionOP,
  title={Induction of protective immunity by Legionella pneumophila flagellum in an A/J mouse model.},
  author={Maria Luisa Ricci and Antonella Torosantucci and Maria Scaturro and Paola Chiani and Lucilla Baldassarri and Maddalena Castellani Pastoris},
  journal={Vaccine},
  year={2005},
  volume={23 40},
  pages={4811-20}
}
The capacity of a purified preparation of Legionella pneumophila flagella (FLA) to induce protective immune responses was studied in an A/J mouse model. Animals immunized with FLA promptly mounted an anti-FLA antibody response and also developed a strong activation of both innate and adaptive cell-mediated immunity, as shown by an early release of pro-inflammatory cytokines in the peritoneal cavity, and by a positive cutaneous delayed-type hypersensitivity reaction and in vitro splenic… CONTINUE READING