Induction of protective immunity against rabies by immunization with rabies virus ribonucleoprotein ( rabies vaccine / antigen priming / intrastructural antigen recognition / virus-neutralizing antibody / cytolytic T cells )

@inproceedings{Dietzschold2003InductionOP,
  title={Induction of protective immunity against rabies by immunization with rabies virus ribonucleoprotein ( rabies vaccine / antigen priming / intrastructural antigen recognition / virus-neutralizing antibody / cytolytic T cells )},
  author={Bernhard Dietzschold and HONGHAI WANG and Charles E. Rupprecht and Esteban Celis and Maria Tollis and Hildegund C J Ertl and Ellen Heber-Katz and Hilary Prof Koprowski},
  year={2003}
}
We have studied the ability of rabies virus ribonucleoprotein (RNP) to induce a protective immune response in animals against lethal challenge with rabies and rabies-related lyssa viruses. Liposomes containing either RNP or the glycoprotein (G protein) of a variant virus with multiple alterations in the G antigenic structure conferred no or poor protection, respectively, against lethal intracerebral challenge with rabies virus. By contrast, liposomes containing RNP and the variant G protein… CONTINUE READING

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Nature ( London ) 280 , 147 - 148

P. A. Scherle, W. Gerhard
  • Proc . Nat ! . Acad . Sci . USA
  • 1979

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