Induction of protective immunity against Schistosoma mansoni via DNA priming and boosting with the large subunit of calpain (Sm-p80): adjuvant effects of granulocyte-macrophage colony-stimulating factor and interleukin-4.

@article{Siddiqui2003InductionOP,
  title={Induction of protective immunity against Schistosoma mansoni via DNA priming and boosting with the large subunit of calpain (Sm-p80): adjuvant effects of granulocyte-macrophage colony-stimulating factor and interleukin-4.},
  author={Afzal Ahmed Siddiqui and Troy M Phillips and Hugues Charest and Ron B. Podesta and Martha L. Quinlin and Justin R. Pinkston and Jenny D. Lloyd and Michelle Paz and Rachael M. Villalovos and Janet Pompa},
  journal={Infection and immunity},
  year={2003},
  volume={71 7},
  pages={
          3844-51
        }
}
Considerable morbidity and mortality result from schistosomiasis, an affliction affecting an estimated 200 million people. Although schistosomicidal drugs and other control measures (including public hygiene and snail control) exist, the advent of an efficacious vaccine remains the most potentially powerful means for controlling this disease. We have targeted a vaccine candidate (large subunit of calpain, Sm-p80) because of its consistent immunogenicity, protective potential, and integral role… CONTINUE READING

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