Induction of prostate apoptosis by doxazosin in benign prostatic hyperplasia.

@article{Kyprianou1998InductionOP,
  title={Induction of prostate apoptosis by doxazosin in benign prostatic hyperplasia.},
  author={Natasha Kyprianou and Juan P Litvak and Andrew A. Borkowski and Richard E Alexander and Stephen C Jacobs},
  journal={The Journal of urology},
  year={1998},
  volume={159 6},
  pages={1810-5}
}
PURPOSE The molecular mechanisms underlying the therapeutic effect of the alpha1 blocker, doxazosin, on benign prostatic hyperplasia (BPH) are poorly understood. We evaluated the effect of doxazosin on cell proliferation and apoptosis in the prostatic glandular epithelium and stroma of patients with BPH. MATERIALS AND METHODS We examined proliferative and apoptotic activities in prostate specimens of 22 men a mean of 65 years old with BPH before and after doxazosin treatment within the normal… CONTINUE READING