Induction of prostaglandin synthesis as the mechanism responsible for the chills and fever produced by infusing amphotericin B.

@article{Gigliotti1987InductionOP,
  title={Induction of prostaglandin synthesis as the mechanism responsible for the chills and fever produced by infusing amphotericin B.},
  author={Francis Gigliotti and Jerry L. Shenep and Lennie Lott and Donald Thornton},
  journal={The Journal of infectious diseases},
  year={1987},
  volume={156 5},
  pages={784-9}
}
Amphotericin B produces chills and fever in a significant proportion of patients who receive this drug. The mechanism for this adverse effect is unknown. Amphotericin B suspension at a concentration of 1.0 microgram/ml was demonstrated to be a potent inducer of prostaglandin E2 synthesis by human and murine mononuclear cells in vitro. A double-blind, placebo-controlled clinical trial demonstrated that ibuprofen (10 mg/kg), a potent inhibitor of prostaglandin synthesis, administered 30 min… CONTINUE READING
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