Induction of prostacyclin by steady laminar shear stress suppresses tumor necrosis factor-alpha biosynthesis via heme oxygenase-1 in human endothelial cells.

@article{Francesco2009InductionOP,
  title={Induction of prostacyclin by steady laminar shear stress suppresses tumor necrosis factor-alpha biosynthesis via heme oxygenase-1 in human endothelial cells.},
  author={Luigia Di Francesco and Licia Totani and Melania Dovizio and Antonio Piccoli and Andrea Di Francesco and Tania Salvatore and Assunta Pandolfi and Virgilio Evangelista and Ryan A Dercho and Francesca Seta and Paola Patrignani},
  journal={Circulation research},
  year={2009},
  volume={104 4},
  pages={506-13}
}
Cyclooxygenase (COX)-2 is among the endothelial genes upregulated by uniform laminar shear stress (LSS), characteristically associated with atherosclerotic lesion-protected areas. We have addressed whether the induction of COX-2-dependent prostanoids in endothelial cells by LSS plays a role in restraining endothelial tumor necrosis factor (TNF)-alpha generation, a proatherogenic cytokine, through the induction of heme oxygenase-1 (HO)-1, an antioxidant enzyme. In human umbilical vein… CONTINUE READING

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