Induction of propranolol metabolism by Ginkgo biloba extract EGb 761 in rats.

  title={Induction of propranolol metabolism by Ginkgo biloba extract EGb 761 in rats.},
  author={Li-zi Zhao and Ming Huang and Jie Chen and Pui Lai Rachel Ee and Eli Chan and Wei Duan and Y Y Guan and Yun-Han Hong and Xiao Chen and Shufeng Zhou},
  journal={Current drug metabolism},
  volume={7 6},
Ginkgo biloba is one of the most popular herbal medicines in the world, due to its purported pharmacological effects, including memory-enhancing, cognition-improving, and antiplatelet effects. When used in the elderly, Ginkgo has a high potential for interactions with cardiovascular drugs. This study aimed to investigate the effects of the standard Ginkgo biloba extract (EGB 761) treatment on the pharmacokinetics of propranolol and its metabolism to form N-desisopropylpropranolol (NDP) in rats… 
Pharmacokinetic drug interactions involving Ginkgo biloba
  • M. Unger
  • Medicine, Biology
    Drug metabolism reviews
  • 2013
Regarding pharmacokinetic herb–drug interactions, the intake of the standardized GLE, EGb 761, together with synthetic drugs appears to be safe as long as daily doses up to 240 mg are consumed, but if this applies to other extracts prepared according to the European Pharmacopoeia remains uncertain.
Pharmacokinetics and metabolism of jatrorrhizine, a gastric prokinetic drug candidate
The metabolic properties of jatrorrhizine suggest multiple metabolic pathways, which will contribute to promote further research and development of the natural gastric prokinetic drug candidate.
Bilobalide in ginkgo biloba extract is a major substance inducing hepatic CYPs
It is indicated that bilobalide is the major substance in GBE that induces hepatic CYPs, and treatment with GBE and with bilobalides greatly induced pentoxyresorufin O‐dealkylase activity.
Studies on Chemical Characterization of Ginkgo Amillaria Oral Solution and Its Drug–Drug Interaction With Piceatannol 3′-O-β-D-Glucopyranoside for Injection
Ginkgo Amillaria oral solution (GAO) is commonly used for the treatment of cardiovascular and cerebrovascular diseases in China. Piceatannol-3′-O-β-D-glucopyranoside for injection (PGI) is mainly
Ginkgo biloba extract attenuates warfarin-mediated anticoagulation through induction of hepatic cytochrome P450 enzymes by bilobalide in mice.
Oxidative demethylenation and subsequent glucuronidation are the major metabolic pathways of berberine in rats.
Present study was designed to explore roles of metabolic clearance in the disposition of berberine (BBR) in rats, with a focus on oxidative metabolism and subsequent glucuronidation. Plasma from rats
The Clinical Importance of Herb-Drug Interactions and Toxicological Risks of Plants and Herbal Products
This review can be used as a quick reference database for physicians and healthcare professionals involved in therapy, aiming to maximize clinical outcomes by reducing the negative and toxic effects of plants along with avoiding herb-drug interactions.
Biologic effects of fenbendazole in rats and mice: a review.
Data from other animal species suggest that the ability of B and T lymphocytes to proliferate in the secondary immune response may be suppressed during treatment with FBZ, and findings from toxicologic, carcinogenic, immunologic, and metabolic studies on fenbendazole are summarized.
Effect of Ginkgo biloba on blood pressure and incidence of hypertension in elderly men and women.
Although baseline hypertension status did not modify the antihypertensive effects of G. biloba, it did influence the changes in BP variables observed during follow-up, with decreases in hypertensives, increases in normotensive, and no changes in prehypertensives.