Induction of prophage and mutagenic effects by alkyl alkylaminosulfonates, ethyl aminosulfonate and alkyl methanesulfonates.

@article{Sssmuth1980InductionOP,
  title={Induction of prophage and mutagenic effects by alkyl alkylaminosulfonates, ethyl aminosulfonate and alkyl methanesulfonates.},
  author={R. S{\"u}ssmuth},
  journal={Mutation research},
  year={1980},
  volume={78 4},
  pages={
          301-15
        }
}
  • R. Süssmuth
  • Published 1 August 1980
  • Chemistry
  • Mutation research
4 Citations

References

SHOWING 1-10 OF 22 REFERENCES

Induction of Rat Kidney Tumours by Ethyl Methanesulphonate and Nervous Tissue Tumours by Methyl Methanesulphonate and Ethyl Methanesulphonate

It is reported that the simple alkylating agent ethyl methanesulphonate will induce a high incidence of primary kidney tumours, indistinguishable in histological appearance from those induced by dimethylnitrosamines and N-methyl-N-nitrosourea.

Prophage induction by alkylating ethyl methylaminosulfonate.

Treatment of the lysogenic strain M. lysodeikticus 53-40 (N5) with ethyl methylaminosulfonate results in a slight increase in infective center concentration of N5 phages which is only detectable once

ALKYLATION OF RAT BRAIN NUCLEIC ACIDS BY N‐METHYL‐N‐NITROSOUREA AND METHYL METHANESULPHONATE

Alkylation of rat brain nucleic acids in vivo was measured after a single intravenous injection of N‐[14C]methyl‐N‐nitrosourea and methyl methanesulphonate and the main product was 7‐methylguanine, which resulted in varying small amounts of methylation of other nucleic acid bases.

Quantitative forward mutation assay in Salmonella typhimurium using 8-azaguanine resistance as a genetic marker.

A quantitative forward mutation assay using Salmonella typhimurium, in which resistance to the purine analog 8-azaguanine is used as a genetic marker is developed, and the relative merits of forward versus reverse mutation assays are discussed.

CHEMICAL MUTAGENS: PRINCIPLES AND METHODS FOR THEIR DETECTION

This book describes the detection of genetic damage in mammalian sperm both at specific loci and over the entire genome as a predictor of heritable genetic damage and other endpoints.

Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.

There is a high correlation between carcinogenicity and mutagenicity: 90% (156/174) of carcinogens are mutagenic in the test and despite the severe limitations inherent in defining non-carcinogenicity, few "non-Carcinogens" show any degree of mutageniability.

Induction of Phage Formation in the Lysogenic Escherichia coli K-12 by Mitomycin C

This communication concerns the lytic process of Escherichia coli K–12 induced by mitomycin C added externally, and suggests that this antibiotic could induce the development of active phage from the prophage state in lysogenic bacteria, since they are similar to ultra-violet effects.

INDUCTION OF LYSOGENIC MICROCOCCUS LYSODEIKTICUS

Between 50 and 60% of log-phase cells of Micrococcus lysodeikticus strain ML 53-40, lysogenic for N5 bacteriophage, were induced by an optimal dose of ultraviolet light, and induction of dilute cell suspensions caused a subsequent 200- to 800-fold increase in infective-center concentration.