Induction of proliferation or hypertrophy of chondrocytes in serum-free culture: the role of insulin-like growth factor-I, insulin, or thyroxine

@article{Bhme1992InductionOP,
  title={Induction of proliferation or hypertrophy of chondrocytes in serum-free culture: the role of insulin-like growth factor-I, insulin, or thyroxine},
  author={K B{\"o}hme and M Conscience-Egli and T Tschan and Kaspar H. Winterhalter and Peter Bruckner},
  journal={The Journal of Cell Biology},
  year={1992},
  volume={116},
  pages={1035 - 1042}
}
In bone forming cartilage in vivo, cells undergo terminal differentiation, whereas most of the cells in normal articular cartilage do not. Chondrocyte hypertrophy can be induced also in vitro by diffusible signals. We have identified growth factors or hormones acting individually on 17-d chick embryo sternal chondrocytes cultured in agarose gels under strictly serum-free conditions. Insulin-like growth factor I or insulin triggered the first steps of chondrocyte maturation, i.e., cell… CONTINUE READING