Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease?

@article{Cheung2002InductionOP,
  title={Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease?},
  author={C. Cheung and Llm Poon and A. Lau and W. Luk and J. Peiris},
  journal={The Lancet},
  year={2002},
  volume={360},
  pages={1831-1837}
}
  • C. Cheung, Llm Poon, +2 authors J. Peiris
  • Published 2002
  • Medicine, Biology
  • The Lancet
  • BACKGROUND In 1997, the first documented instance of human respiratory disease and death associated with a purely avian H5N1 influenza virus resulted in an overall case-fatality rate of 33%. The biological basis for the severity of human H5N1 disease has remained unclear. We tested the hypothesis that virus-induced cytokine dysregulation has a role. METHODS We used cDNA arrays and quantitative RT-PCR to compare the profile of cytokine gene expression induced by viruses A/HK/486/97 and A/HK… CONTINUE READING
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