Induction of programmed cell death in human hematopoietic cell lines by fibronectin via its interaction with very late antigen 5

@article{Sugahara1994InductionOP,
  title={Induction of programmed cell death in human hematopoietic cell lines by fibronectin via its interaction with very late antigen 5},
  author={Hideyo Sugahara and Yuzuru Kanakura and Takuma Furitsu and Katsuhiko Ishihara and Kenji Oritani and Hisami Ikeda and Hitoshi Kitayama and Jun Ishikawa and Kyoko Hashimoto and Yoshio Kanayama},
  journal={The Journal of Experimental Medicine},
  year={1994},
  volume={179},
  pages={1757 - 1766}
}
Extracellular matrix (ECM) molecules such as fibronectin (FN), collagens, and laminin have important roles in hematopoiesis. However, little is known about the precise mechanisms by which ECM molecules regulate proliferation of human hematopoietic progenitor cells. In this study, we have investigated the effects of ECM molecules, particularly of FN, on the proliferation of a myeloid leukemia cell line, M07E, which proliferates in response to either human granulocyte/macrophage colony… CONTINUE READING

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o~4fll and o~5fll are differentially expressed during mydopoiesis and mediate the adherence of human CD34 + cells to fibronectin in an activation-dependent

J. M. Kerst, J. B. Sanders, +5 authors C. E. van der Schoot
1993
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