Induction of potent and long-lasting CD4 and CD8 T-cell responses against hepatitis C virus by immunization with viral antigens plus poly(I:C) and anti-CD40.

Abstract

Development of vaccination strategies against hepatitis C virus (HCV) is of paramount importance. With this aim, we tested the ability of dendritic cell-activating reagents polyinosinic-polycytidylic acid (poly(I:C)) and anti-CD40, as adjuvants to induce T-cell responses against HCV. Immunization of mice with these adjuvants induced dendritic cell… (More)

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@article{Zabaleta2007InductionOP, title={Induction of potent and long-lasting CD4 and CD8 T-cell responses against hepatitis C virus by immunization with viral antigens plus poly(I:C) and anti-CD40.}, author={Aintzane Zabaleta and Laura Arribillaga and Diana Ll{\'o}piz and Javier Dotor and Juan J Lasarte and Jes{\'u}s Prieto and Francisco Borr{\'a}s-Cuesta and Juan I. Esteban and Josep Quer and Francesc Vayreda and Pablo Sarobe}, journal={Antiviral research}, year={2007}, volume={74 1}, pages={25-35} }