Induction of postsurgical tumor immunity and T-cell memory by a poorly immunogenic tumor.


The generation of protective CD8 T-cell memory against tumor-expressed self-antigens is an important but elusive goal of cancer immunotherapy. The possibility that a progressive, poorly immunogenic tumor can induce T-cell memory against self-antigens has not previously been studied. Herein, we report that growth of the poorly immunogenic B16 melanoma in the absence of regulatory T cells (T(reg)) generates CD8 T-cell responses that develop into functional memory after the tumor has been surgically excised. Tumor-primed memory T cells recognized melanocyte differentiation antigens TRP-2/DCT and gp100 and persisted for as long as 5 months following surgical tumor excision. Phenotypic analysis showed that these cells develop into both central and effector memory T-cell subsets, which produce IFN-gamma and interleukin-2 on reencounter with antigen. Most importantly, tumor-primed memory T cells mediated the rejection of intradermal and systemically disseminated challenge tumors given 30 to 60 days following surgery. Tumor-excised mice also developed autoimmune vitiligo, showing that T(reg) cells prevent tissue-specific autoimmunity in tumor-bearing hosts. This study establishes that T(reg) depletion in tumor-bearing hosts drives the natural development of protective T-cell memory. Generating such responses may aid in the clinical management of tumor recurrence and metastasis following surgery.

5 Figures and Tables

Citations per Year

157 Citations

Semantic Scholar estimates that this publication has 157 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Zhang2007InductionOP, title={Induction of postsurgical tumor immunity and T-cell memory by a poorly immunogenic tumor.}, author={Peisheng Zhang and Anik L. C{\^o}t{\'e} and Victor Christoff de Vries and Edward J. Usherwood and Mary Jo Turk}, journal={Cancer research}, year={2007}, volume={67 13}, pages={6468-76} }