Induction of posterior vitreous detachment in rabbits by intravitreal injection of tissue plasminogen activator following cryopexy.

@article{Hesse2000InductionOP,
  title={Induction of posterior vitreous detachment in rabbits by intravitreal injection of tissue plasminogen activator following cryopexy.},
  author={Lutz Hesse and Bruno Nebeling and Bernd Schroeder and Glenn Heller and P. Kroll},
  journal={Experimental eye research},
  year={2000},
  volume={70 1},
  pages={31-9}
}
The purpose of this study was to generate intravitreal plasmin after intravitreal injection of tissue plasminogen activator (TPA) and cryopexy, and to assess its proteolytic effect on the vitreoretinal border region.Twenty-four hr after a mild cryopexy, 25 microg recombinant tissue plasminogen activator (TPA) was injected into the vitreous cavity, the fellow eye received an intravitreal injection of the same volume of buffered salt solution. Light, scanning and transmission electron microscopy… CONTINUE READING

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