Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line

@article{Watabe1994InductionOP,
  title={Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line},
  author={Masakazu Watabe and Akira Nagafuchi and Shoichiro Tsukita and Masatoshi Takeichi},
  journal={The Journal of Cell Biology},
  year={1994},
  volume={127},
  pages={247 - 256}
}
PC9 lung carcinoma cells cannot tightly associate with one another, and therefore grow singly, despite their expression of E-cadherin, because of their lack of alpha-catenin, a cadherin-associated protein. However, when the E-cadherin is activated by transfection with alpha-catenin cDNA, they form spherical aggregates, each consisting of an enclosed monolayer cell sheet. In the present work, we examined whether the alpha-catenin-transfected cell layers expressed epithelial phenotypes, by… CONTINUE READING

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