Induction of placental alkaline phosphatase in choriocarcinoma cells by 5-bromo-2′-deoxyuridine

@article{Chou2007InductionOP,
  title={Induction of placental alkaline phosphatase in choriocarcinoma cells by 5-bromo-2′-deoxyuridine},
  author={Janice Y. Chou and J. C. Robinson},
  journal={In Vitro},
  year={2007},
  volume={13},
  pages={450-460}
}
SummaryGrowth of choriocarcinoma cells in the presence of 5-bromo-2′-deoxyuridine (BrdUrd) results in a 30- to 40-fold increase in alkaline phosphatase activity. The effect of BrdUrd is specific for phosphatase with an alkaline pH optimum. The induction by BrdUrd is probably not due to the production of an altered enzyme, since the induced enzyme resembles the basal enzyme in thermal denaturation and kinetic properties.Enzyme induction can be prevented by thymidine but not by deoxycytidine or… Expand
Regulation of the induction of alkaline phosphatase in choriocarcinoma cells by sodium butyrate
  • J. Chou
  • Biology, Medicine
  • In Vitro
  • 2007
TLDR
Alkaline phosphatase is induced in human choriocarcinoma cells by short-chain fatty acids, especially sodium butyrate, and requires cellular synthesis of protein, RNA and DNA. Expand

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