Induction of physiological thermotolerance in MDCK monolayers: contribution of heat shock protein 70.

@article{Dokladny2006InductionOP,
  title={Induction of physiological thermotolerance in MDCK monolayers: contribution of heat shock protein 70.},
  author={Karol Dokladny and Walker Wharton and Rebecca Lobb and Thomas Y. Ma and Pope Lloyd Moseley},
  journal={Cell stress & chaperones},
  year={2006},
  volume={11 3},
  pages={268-75}
}
Enhanced survival of both individual cells and whole organisms following a heat stress is termed thermotolerance. In organisms, the maintenance of tissue function rather than the survival of individual cells ultimately determines outcome following thermal challenge. We used MDCK kidney epithelial cells to compare alterations in chaperone activity (as a measure of cellular tolerance) and epithelial barrier function (as a measure of physiological tolerance) after thermal challenge. Quercetin, an… CONTINUE READING

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Thermotolerance and heat acclimation may share a common mechanism in humans.

American journal of physiology. Regulatory, integrative and comparative physiology • 2011
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