Induction of physical dependence upon ethanol and the associated behavioral changes in rats

Abstract

This paper reports findings relative to a simple, rapid and reproducible technique for the induction of physical dependence upon ethanol in the rat. The dependence was induced by intragastric intubation of 20% (w/v) ethanol solutions at 9–15 g/kg in 3–5 fractional doses daily for 4 days, maintaining blood ethanol concentrations above a threshold level… (More)
DOI: 10.1007/BF00429258

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